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Although its physiological role remains unclear, DSIP illustrates several concepts applicable to other brain peptides

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Additionally, 1,8-diMQ and 5-amino-1MQ showed little inhibition of COMT at maximal tested concentrations of 200 M (20% inhibition) and 600 M (10% inhibition), respectively, although no clear trend of concentration-dependent inhibition was observed

Same 0.5 mg of semaglutide in all three cases